Proton pump inhibitor-induced hypomagnesemia: A new challenge

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Hypomagnesemia associated with a proton pump inhibitor.

Severe hypomagnesemia is a serious clinical condition. Proton pump inhibitor (PPI) induced hypomagnesemia has been recognized since 2006. In March 2011 the U.S. Food and Drug Administration advised that long-term use of PPI can induce hypomagnesemia. We report the first Japanese case of hypomagnesemia associated with chronic use of PPIs in a 64-year-old man hospitalized for nausea, bilateral an...

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Hypomagnesemia and proton-pump inhibitors.

INTRODUCTION Proton pump inhibitors (PPIs) have been linked to clinically symptomatic hypomagnesemia. AREAS COVERED We searched Medline database in all languages using 'proton-pump inhibitors, magnesium, hypomagnesemia and hypomagnesemic hypoparathyroidism' as search terms and other articles were identified through searches of the files of the authors and reference lists from relevant article...

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Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors

In 2006, hypomagnesemia was first described as a complication of proton-pump inhibitors. To address this issue, we systematically reviewed the literature. Hypomagnesemia, mostly associated with hypocalcemic hypoparathyroidism and hypokalemia, was reported in 64 individuals on long-term proton-pump inhibitors. Hypomagnesemia recurred following replacement of one proton-pump inhibitor with anothe...

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ypomagnesemia is an uncommon biochemical change in utpatients, but may be detected in up to 12% of hositalized patients, in whom factors such as total and nteral nutrition, diuretic use, diarrhea, hypoalbuminemia, nd nephrotoxic drugs (antibiotics, chemotherapeutic, etc.) lay a significant role in its occurrence. Symptoms related to ypomagnesemia usually occur with serum magnesium levels ower t...

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ژورنال

عنوان ژورنال: World Journal of Nephrology

سال: 2012

ISSN: 2220-6124

DOI: 10.5527/wjn.v1.i6.151